Overdose

The leading cause of overdose is "too much Drugs". Every dose has a different value of Drugs.

For the most recent info, go straight to the XML. The relevant files are \Mods\Core\Defs\HediffDefs\Hediffs_Global_Misc.xml and everything in Mods\Core\Defs\Drugs\.

Let's say you start overdosing at 0.6 units of Drugs, because you do. Let's say you start dying at 1 whole Drugs, because you do.

Go-Juice, Flake, Yayo and Wake-up contain anywhere between 0.18 and 0.35 Drugs per dose. Malari-block contains between 0.08 and 0.14 Drugs.

That means that sometimes it's safe to take a wonderful speedball of Go-Juice, Yayo and Wake-up for the best day in your life. Sometimes you take that speedball and it's the last day in your life.

You cannot overdose on Smokeleaf, no matter how many you inject. It's entirely possible to die from smokeleaf, but that's technically not dying from an overdose.