Overdose

The only cause of Overdose is to consume an excess amount of drugs in a short time period, before Blood Filtration has the time to deal with it.

The severity of a Drug Overdose is determined by what drugs are consumed; with social drugs (i.e. Beer, Smokeleaf) and Luciferium not contributing to overdoses, hard drugs (i.e. Go-Juice, Flake, Yayo, Wake-up) increasing the severity by 0.18-0.35 per drug consumed, and Penoxycyline being an outsider with a severity increase by 0.08-0.14.

Stages

There are four stages of Drug Overdose in RimWorld:

• Hidden (severity: <0.60)
  • No effect, within tolerable levels of hard drug consumption
  • Doesn't show on the health tab of colonists
• Minor (severity: 0.6—<0.75)
  • Reduces the affected pawn's consciousness by 50%
    • Note this isn't 'Consciousness max: 50%'
  • Frequent vomiting
    • Every 0.3 days (4.8h) on average
• Major (severity: 0.75—<1)
  • Pawn will lose consciousness (Consciousness max: 10%)
  • Small chance to become fatal
• Fatal/Extreme (severity: 1)
  • Overdosing pawn's body is unable to handle extreme drug levels, and succumbs
  • Still shows up as 'Major' in health tab