Bliss lobotomy
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Bliss lobotomy is a surgical operation that makes the patient happier while rendering them incapable of intellectual and skilled labor. The operation requires a minimum medical skill of 4, and costs 
30 Bioferrite. The surgery has a base 100% Success Rate Multiplier and a 10% chance the patient pawn dies on failure.
A Gorehulk must be encountered before the Bliss Lobotomy research option is unlocked as a basic void research project, which requires 25 points of void research to complete.
Bliss lobotomy confers a +20 mood bonus, reduces Global Learning Factor by −50%, and disables the Cook, Construct, Grow, Mine, Plant Cut, Smith, Tailor, Craft, Research and Dark Study work types. Additionally, Bliss Lobotomy increases Prison Break Inverval by 1000%.
Pawns that are Bliss Lobotomized will remain as such even if turned into Ghouls.
Healer mech serum and Unnatural healing can reverse a bliss lobotomy. The biosculpter bioregeneration cycle will not heal a bliss lobotomy.
Analysis
Bliss lobotomized pawns can still serve as Wardens, Artists, Doctors, and Animal Handlers. The procedure itself does not reduce consciousness, meaning that pawns will still move with the same speed as before, unlike installing a Joywire. Having a dramatically reduced learning speed will restrict pawn growth, making Bliss Lobotomies more useful on pawns who already have high skill in unaffected work types, particularly Yttakin who have the Great Animals gene for +8 to animals skill and the Aggressive gene which the mood bonus makes less severe.
A Bliss Lobotomy gives a net +10 mood bonus when used on a pawn with the Very Unhappy gene, which gives a hefty +5 metabolism.
Bliss Lobotomies might be attractive to players looking to cut down on the number of prison breaks their prisoners attempt but who don't want to go through the 4 surgeries required to install peg legs and then remove said peg legs.