Wouldn't cryptosleep caskets or alternatively anesthetizing every obsessed pawn before destruction or hell even storing them in transport pods without launching be used to prevent this? and i suppose cryptosleep caskets can be used to "reserve" a pawn for destroying it if it doesn't "infect" pawns in stasis. Oh yeah and do violence disabled and dead calm genes also prevent this mental break or is it overridden by the cube.
Topic on Talk:Golden cube
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Unfortunately was unable to test much as I found much of this info within a solo colonist run with only early to mid level techs and slight help from temporary pawns. All great questions which need dedicated testing.
From my playthrough, I can confirm that sedating pawns prevents them from going berserk. Have not tested cryptosleep or transport pods.