Drugs
Drugs can be useful to gain temporary benefits of various sorts, but can lead to harmful addictions, negative side effects, and even overdose resulting in permanent ailments or death. Most drugs are crafted at the drug lab using either psychoid leaves or neutroamine. Beer, however requires hops and has an intermediate stage before fermenting called wort.
If you want to avoid drugs in your colony, you have the option of burning them at a campfire or crematorium, or forbidding them and selling them to a trader which is lucrative on the market. Binging pawns will take drugs even if they're forbidden though. The effects of drugs are modulated by body size, so smaller creatures need less beer to be drunk than bigger animals such as the Thrumbo.
Drugs can be assigned for regular taking through the drug policy system. Similar to Outfits, drug policies are an assigned schedule for taking drugs. You can set any number of drugs, each with a frequency. For example, you can assign a colonist to drink 2 beers every day, and take one Penoxycyline every 5 days. You can also toggle to use the drug to feed an addiction, separately from joy usage.
Drugs can also be administered through a medical operation. Animals may take drugs on their own if they are within their allowed areas.
Addiction and Tolerance
Addictions are a sad reality that most drug-using colonies must face. Without a continuous supply of drugs, withdrawal symptoms will kick in and your poor colonist will suffer. Luciferium has an instant addiction. Once taken, it will need to be taken regularly. Otherwise, the withdrawal from it will cause all sorts of mental breaks, eventually resulting in death.
Tolerance is the value related to addiction upon consumption of any drugs. It has a fixed buildup amount for each drug, and decreases each day afterwards. Tolerance gain is inversely proportional to body size, so smaller colonists (teenagers 0.85 vs normal 1.0) gain more tolerance per drug use. Colonists will have a chance of getting addicted once they cross a certain tolerance threshold. Safe consumption of drugs can be set in the restriction tab for drug usage.
When tolerant, the severity given per dose of the drug will decrease by a fixed amount, meaning that they will last shorter, and colonists will need to consume more of them.
Addiction also has the same effect, in addition to requiring the pawn get a regular dose of the drug to prevent withdrawal.
| Drug | High duration per dose | Tolerance gain per dose | Tolerance fall rate | New addiction min tolerance | New addiction chance | Safe dose interval | Safe doses at 0 tolerance |
|---|---|---|---|---|---|---|---|
| Ambrosia | 16.7 h | 3.2% | 2% / Day | 15% | 1% | 1.6 Days | 4 |
| Psychite tea | 7.2 h | 3% | 1.5% / Day | 10% | 2% | 2 Days | 3 |
| Beer | 4.8 h | 1.6% | 1.6% / Day | 25% | 1% | 1 Day | 15 |
| Smokeleaf | 12 h | 3% | 1.5% /Day | 15% | 2% | 2 Days | 5 |
| Flake | 7.2 h | 4% | 1.5% / Day | 0% | 5% | Never | 0 |
| Yayo | 12 h | 4% | 1.5% / Day | 0% | 1% | Never | 0 |
| Wake-up | 12 h | N/A | N/A | 0% | 2% | Never | 0 |
| Go-juice | 16.7 h | N/A | N/A | 0% | 2.6% | Never | 0 |
- Tolerance gain values are for size 1.00 colonists (normal).
Fighting Addictions
Addiction Severity
Time spent in withdrawal is calculated by multiplying addiction severity by recovery time. This means that the addiction takes longer to cure for each dose the addict takes to a maximum of 100%.
Drug binges
Colonists with either the Chemical Interest or Fascination traits as well as addicts may randomly have drug binges. Such colonists will ignore drug policies. This can cause a relapse from getting those colonists clean.
Remove access to drugs
Colonists can't take drugs that they can't reach. A drug binging colonist without access to that drug will only wander around until their senses are restored. Other withdrawal-based mental breaks are another story.
To destroy drugs, you can burn them at a campfire. You can also sell them to passing traders that are interested in buying, or have a non-binging colonist take them away on a caravan.
One alternative to keeping drugs out of the hands of binging addicts is to place the drugs in a room and wall up the entrance. This could also be done to the addict by trapping them but will become counterproductive once they become hungry. Another alternative, which may be quicker depending on the case, is to load the drugs in a transport pod and keep them there until the binge is over.
'Rehab center'
Instead of keeping the drugs from the addict, you can keep the addict from the drugs by imprisoning them and keeping them there until they're clean. Imprisoning them also contains the impacts of their mental breaks. You can arrest an addicted colonist by drafting another colonist and right clicking on the addict. Using force can have a negative social influence on the patient and increased mood debuffs that will make recovery even harder, especially if such measure was performed with weapons (healing will take longer and could injure the body badly). As with any combat, either or both of the addicted or the arresting colonist have the chance of injury or death. It may be best to wait until the withdrawal-suffering pawn collapses due to exhaustion or starvation, and then arrest them without the risk of a physical confrontation. If it must be done while they can stand, then it's wise to disarm this colonist before attempting to arrest them as they may resist and go berserk. Still, addicted colonists will usually go down quickly due to the consciousness penalty from withdrawal.
Chatting with the imprisoned while they're getting clean will help train your warden's Social skill. Still, arresting any colonist will give them the accompanying thoughts of being imprisoned both during and afterward.
This also works great for addicted prisoners as they're already imprisoned. It is recommended to keep them in their own cell though. Otherwise, they can go berserk and attack other prisoners. If you want to recruit such an addict, it's recommended to get them clean before recruiting. There's no use in releasing an addicted new recruit, only to throw them right back in their cell very soon.
You can avoid the berserk state of a "drug rehab inmate" by installing and then removing peg legs to keep them incapacitated until new (and possibly better depending on technological level) replacement legs get reinstalled after the addiction ends. This trick can also be done by installing and removing a bionic spine which is half as costly as double bionic legs but does not make the pawn faster. Make sure you have prosthetics or bionics researched if you want to do this method of rehabilitation.
Recovery
Withdrawal will make the person feel a great mood drop and impair their stats, depending on the addicted drug. Once the withdrawal passes away, the colonist will feel good as new.
During this time, you may want to give your colonist more time to enjoy himself. Giving him social drugs may help depending on the situation, but remember never to feed his addiction as this resets the withdrawal countdown, unless he's addicted to multiple drugs at the same time, in which it may be easier to deal with 1 drug addiction at a time.
On the other hand, if they become incapacitated when the withdrawal symptoms hit all at once, it may be better to leave them like that, as they are unable to have mental breaks or such during the withdrawal period.
The health overview tab which will display a counter with withdrawal percentage. The higher it gets, the closer to complete recovery (100%, though 99.5% is rounded to 100% in display).
Healer mech serum
Using the healer mech serum instantly treats non-luciferium drug addictions if there are no other serious health problems affecting the addict. This gives a convenient but somewhat costly way to bypass the lengthy withdrawal period. Note however healer mech serum cannot remove the luciferium need. There is no cure for luciferium addiction.
Effects
Not surprisingly, different drugs have different effects, and some also have different effects depending how much is consumed. Some effects can be beneficial to a colonist or a colony, although many drugs have a mixture of good and bad effects, and some can be helpful to the colony as a whole while putting the individual colonist at great risk. Also, effects and duration can be reduced by tolerance to a drug.
Note that many drugs have a chance of heart attack or instant addiction, even for a single, first use, and such chances are always increased when multiple drugs are active in a pawn's system at the same time - see the above section on addition & tolerance for more information.
When and What to Use
- EDITOR'S NOTE, April 10, '22 - In creating this table, several values were found to differ in different articles, and others were suspect. For instance, Yayo has both "+15" and "-20" listed for Movement on its own article - but Yayo also has -20 Consciousness (which directly affects Move!). If "-20 Move" is correct, that adds to a total -40, but if +15 then only a net -5 Move - so which is correct? The collective editors are looking in to these discrepancies and will correct once there is confirmation, please be patient, thx.
The table below lists the most common effects; see notes, below, for descriptions and for "other" effects.
- Note that Consciousness ("Consc") is an extremely important consideration when giving drugs for two primary reasons.
- First, any change in Consciousness translates directly to an identical change in both Manipulation and Moving, both of which cascade to other stats. Values listed under "Move" are separate for additional changes, and do not reflect any additional effect from a change in Consciousness.
- Second, Consciousness can be life-or-death for patients or any pawn that may have that stat additionally reduced for any reason. Any pawn loses consciousness when this falls below 30%, and dies when this reaches 0%. Note also that some drugs increase consciousness, which could be a lifesaver in situations where consciousness is threatening to drop to an undesirable level.
| Drug | Time | Consc | Mood | Rec | Pain | Rest | Tired | Move | Other |
|---|---|---|---|---|---|---|---|---|---|
| Ambrosia | 16.7 h | - | 50% | - | - | - | - | +0.2 Nut | |
| Beer (1st*) | 4.8 h | - | 10 | 17% | -10% | - | - | - | +0.08 Nut, see notes* |
| Psychite tea | 7.2 h | - | 40% | -10% | +10% | x80% | - | ||
| Smokeleaf | 12 h | -30% | 13 | 80% | -20% | -10% | - | - | - |
| Flake | 7.2 h | - | 70% | 50% | - | 33% | - | - | |
| Go-juice | 16.7 h[45 hours?] | +20% | 40% | 10% | +40% | x33% | +50% | see notes* | |
| Wake-up | 12 h | +10% | 0 | 40% | - | 100% | x80% | +10% | +50% GWS see notes* |
| Yayo | 12 h | -20% | 80% | 50% | - | x33% | +15%* | - |
Effect categories have been abbreviated to avoid an awkwardly large table. If several drugs share an effect, they are listed; drugs with (relatively) unique effects are listed in "other". Though some may be obvious, they are:
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|
- Notes
- Ambrosia - This has a nutritional value.
- Beer - The 1st beer gives 98% Manipulation and also increases "Social Fight Chance" by x1.5. Beer also has a small nutritional value. Note that the very first beer has the effects listed, but additional beers can have additional negative effects, including a major drop in Consciousness. See Beer for more information.
- Smokeleaf - Hunger rate offset +30% (i.e. the pawn gains hunger 30% faster).
- Go-juice - +35% sight; restores +15% psyfocus
. Note that 20% improved consciousness translates to +20% improved manipulation and talking, and improved sight also cascades to other stats, all together yielding a +20% increase in General Labor Speed, improved combat stats and in Medical Tend Quality and surgery success chances ; see detailed effects of go-juice.
- Note: To be clear, a pawn high on go-juice only feels 10% of the pain they suffer. In combat, this usually means they are not "downed" from severe injuries, they fight until they win or are killed outright.
- Wake-up - Increases Global Work Speed by +50%.
- Yayo - The "+15" to Movement is directly offset by -20 Consciousness, yielding a net -5 Movement.
Safety considerations
To avoid the downsides of drugs, the following is advised:
- Beer can be safely drunk every day, providing a decent +10 mood.
- Psychite tea can be consumed every two days, providing an additional +12 mood.
- If an ambrosia sprout happens, 200 or so ambrosia can be harvested and one consumed every 2 days (actually 1.6) for +5 mood.
- Smokeleaf joints can also be smoked every 2 days, providing a +12 boost, but also massively reduces consciousness, and should thus be used sparingly.
- Penoxycyline should be taken every 5 or 6* days to mitigate 3 dangerous diseases, however this might not be worth it if the current biome has a disease frequency less than 0.5.
- (* Penoxycyline lasts ~5.556 days, so it's up to you whether to take it a bit too often, or risk that down time.)
Hard drugs should only be consumed in an emergency:
- Yayo is useful for periods of heavy mood penalties such as family deaths and for difficult or lengthy combats. Providing a massive +35 mood, +10% Moving, halving pain, providing 80% recreation and both refilling the Rest need by 40% and reducing further Rest loss. It is a strong mood controller and a fairly potent combat drug, making pawns better fighters and preventing them from breaking, but with a 1 percent addiction chance each time, regardless of tolerance, it is not without risk. It also pales in comparison to go-juice in combat potential.
- Flake should almost never be smoked although it is cheaper and provides the same mood buffs, it has a gigantic 5% addiction chance each. A key exception are perhaps Guests, as they will leave shortly and there is little practical downside to their their addiction.
- Go-juice is an exceptionally potent combat drug, significantly reducing pain and buffing several key capacities and almost every stat. it also restores a modest amount of psyfocus . This is especially useful used when utilizing kiting combat tactics, as it increases the speed of a pawn by 50 percent.
- Wake-up is very useful in situations where something needs to be finished as soon as possible or when a pawn cannot stop working, such as constructing solar panels during a toxic fallout power shortage, or letting your doctor keep saving lives after a devastating raid. It not only makes pawns work faster and better, it provides a full nights rest and significantly reducing rest fall rate, allowing pawns to work for almost three days straight.
During the late game, when silver is plentiful, you can have two or three luciferium addicted colonists. Alternatively, you can go wild and just get everybody addicted to every drug in-game.
Trade
Drugs, especially hard drugs, can be manufactured and sold for a large profit. Below are the optimal types of drugs for sale.
Psychoid-Type
Yayo costs 8 Psychoid leaves and is valued at 21 silver each. It weighs 50 grams and takes 6 work to make. On the other hand, flake takes 4 psychoid leaves and is valued at 14 silver each. It also weighs 50 grams and takes 5 work to make. Psychite tea, however, is the most inefficient. It takes the same amount of leaves as flake, but is 4 silver less valuable than it. On the market, flake is worth 2/3rds the silver of yayo, requires 80% of the Work To Make, and 50% of the ingredient costs. The most economical option depends on which is the greater bottleneck: converting the leaves to the drug, or producing the leaves in the first place.
If converting the leaves into drugs is the bottleneck then there are two options. The psychoid leaves could be turned into yayo, however converting as much as possible to flake and then selling the remaining psychoid leaves themselves is even more efficient. For example, a pawn requires 35,000 ticks (9.72 mins) of work and 800 psychoid leaves to synthesize 100 yayo worth 
2100. With the same amount of work, a pawn could craft 140 flake worth 1960 and consume 560 of the 800 psychoid leaves. The remaining 240 psychoid leaves are worth 456 for a total of 2416. This is not without its downsides however - fewer traders accept psychoid leaves than accept drugs and without refrigeration, the leaves will eventually rot away. Thus, if the player is likely to caravan to a settlement or receive a relevant trader before they rot entirely away, or can accommodate the refrigeration of leaves long term, converting to flake and selling the remainder of leaves is ideal. If they cannot, converting to yayo for storage may be necessary.
If psychoid leaf production is the bottleneck and there is insufficient leaf supply to fully occupy your drug synthesizers' time, producing flake is the optimum as it produces more value per leaf at the cost of more work.
If caravan weight is a limiting factor, yayo is worth more proportional to mass, however the low weight of all the options mean this is unlikely to be relevant as a single muffalo can carry almost 20 stacks of flake worth over 20,000 silver.
Other Hard Drugs
Wake-up and Go-juice are both made from 2 neutroamine, with go-juice costing an additional unit of yayo. Wake-up is valued at 28 silver and takes 14 units of work to make. Go-juice is valued at 53 silver and takes 50 units of work to make. Because these hard drugs use neutroamine for production, it is generally unadvised to use these as profit drugs because neutroamine is both expensive and can not be made. It is better used for high-quality medicine.
Recipes
| Drug | Market Value | Ingredients | Work Amount | Minimum Skills |
|---|---|---|---|---|
| Wake-up | 35 |  2 Neutroamine |
900 | - |
| Penoxycyline | 18 | 2 Neutroamine |
600 | - |
| Flake | 14 |  4 Psychoid leaves |
250 | - |
| Yayo | 21 | 8 Psychoid leaves |
350 | - |
| Psychite tea | 10 | 4 Psychoid leaves |
400 | Cooking 2 |
| Smokeleaf joint | 11 |  4 Smokeleaf leaves |
450 | - |
| Go-juice | 53 | 2 Neutroamine,  1 Yayo |
600 | - |
| Beer | 12 |  1 Wort |
0 | - |
Social Drugs
Hard Drugs
Medical Drugs
Medicine
Medicine can be used as anesthetic, to improve injury treatment, to fight infection, to treat specific ailments (such as asthma and cancers), to increase surgery success %, and, depending on the recipe, as a component in producing some of the above drugs.
A kit of advanced ultra-tech medical supplies, probably manufactured on a distant glitterworld. It contains advanced polymorphic drugs, nanite diagnostic and healing assisters, a mini-imager, and various multi-use tools.
A pack of herbal concoctions typically extracted from the healroot plant. It is less potent than industrial pharmaceuticals, but much better than nothing.
A kit of industrial-era medical equipment. It contains basic drugs, tools for suturing and bone setting, diagnostic devices, and various pads and fluids.
